English Intern
    Institut für Virologie und Immunbiologie

    Ausgewählte Publikationen

    Ausgewählte Originalforschungsarbeiten zu unkonventionellen T Zellen:  

    Karunakaran MM, Willcox CR, Salim M, Paletta D, Fichtner AS , Noll A, Starick L, Nöhren A, Begley CR, Berwick KA, Chaleil RAG, Pitard V, Dechanet-Merville J, Bates PA, Kimmel B, Knowles,9 TJ Kunzmann V,Walter L, Jeeves M,Mohammed F, Willcox BE, Herrmann T. Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vg9Vd2TCR and Is Essential for Phosphoantigen Sensing. Immunity, 2020 March 17 52, 1–12. doi.org/10.1016/j.immuni.2020.02.014

    Fichtner AS, Karunakaran MM, Gu S, Boughter CT, Borowska MT, Starick L, Nöhren A, Göbel TW, Adams EJ, Herrmann T. Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6697-6707. https://doi.org/10.1073/pnas.1909474117. Epub 2020 Mar 5.

    Fichtner AS, Karunakaran MM, Starick L, Truman RW, Herrmann T. The Armadillo (Dasypus novemcinctus): A Witness but Not a Functional Example for the Emergence of the Butyrophilin 3/Vγ9Vδ2 System in Placental Mammals.Front Immunol. 2018 Feb 23;9:265. doi: 10.3389/fimmu.2018.00265. eCollection 2018

    Starick L, Riano F, Karunakaran MM, Kunzmann V, Li J, Kreiss M, Amslinger S, Scotet E, Olive D, De Libero G, Herrmann T. Butyrophilin 3A (BTN3A, CD277)-specific antibody 20.1 differentially activates Vg9Vd2 TCR clonotypes and interferes with phosphoantigen activation. Eur J Immunol. 2017 Jun;47(6):982-992. doi: 10.1002/eji.201646818. Epub 2017 Apr 27.

    Monzón-Casanova E, Rudolf R, Starick L, Müller I, Söllner C, Müller N, Westphal N, Miyoshi-Akiyama T, Uchiyama T, Berberich I, Walter L, Herrmann T. The Forgotten: Identification and Functional Characterization of MHC Class II Molecules H2-Eb2 and RT1-Db2. J Immunol. 2016 Feb 1K 196(3):988-99.

    Paletta D, Fichtner AS, Hahn AM, Starick L, Beyersdorf N, Monzon-Casanova E, Mueller TD, Herrmann T. The hypervariable region 4 (HV4) and position 93 of the a chain modulate CD1d-glycolipid binding of iNKT TCRs. Eur J Immunol. 2015 Apr 21. doi: 10.1002/eji.201545534. [Epub ahead of print]

    Riaño F, Karunakaran MM, Starick L, Li J, Scholz CJ, Kunzmann V, Olive D, Amslinger S, Herrmann T. Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6. Eur J Immunol. 2014 Sep;44(9):2571-6. doi: 10.1002/eji.201444712. Epub 2014 Jun 30.

    Karunakaran MM, Göbel TW, Starick L, Walter L, Herrmann T. Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos). Immunogenetics. 2014 Apr;66(4):243-54.

    Monzon-Casanova E, Paletta D, Starick L, Müller I, Sant'Angelo DB, Pyz E, Herrmann T. Direct identification of rat iNKT cells reveals remarkable similarities to human iNKT cells and a profound deficiency in LEW rats. Eur J Immunol. 2013 Feb;43(2):404-15.

    Harly C, Guillaume Y, Nedellec S, Peigné CM, Mönkkönen H, Mönkkönen J, Li J, Kuball J, Adams EJ, Netzer S, Déchanet-Merville J, Léger A, Herrmann T, Breathnach R, Olive D, Bonneville M, Scotet E. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gd T-cell subset. Blood. 2012 Sep 13;120(11):2269-79. doi: 10.1182/blood-2012-05-430470. Epub 2012 Jul 5.

    Li J, Herold MJ, Kimmel B, Müller I, Rincon-Orozco B, Kunzmann V, Herrmann T. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. J Immunol. 2009 Jun 15;182(12):8118-24.

    Pyz E, Naidenko O, Miyake S, Yamamura T, Berberich I, Cardell S, Kronenberg M, Herrmann T. The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR. J. Immunol. 2006 Jun 15;176(12):7447-55.

    Rincon-Orozco B, Kunzmann V, Wrobel P, Kabelitz D, Steinle A, Herrmann T. Activation of V gamma 9V delta 2 T cells by NKG2D. J Immunol. 2005 Aug 15;175(4):2144-51.

    Ausgewählte Übersichtsarbeiten:

    Butyrophiline: Verwandte der B7-Familie, γδ-T-Zellrezeptorliganden und vieles mehr. Herrmann T.  Trillium Immunologie 2/2021 https://doi.org/10.47184/ti.2021.02.04

    Immuno-antibiotics: Targeting microbial metabolic pathways sensed by uncvvonventional T cells. Eberl M, Oldfield E, Herrmann T. Immunotherapy Advances, Volume 1, Issue 1 ltab005, https://doi.org/10.1093/immadv/ltab005

    Herrmann T, Karunakaran MM, Fichtner AS. A glance over the fence: Using phylogeny and species comparison for a better understanding of antigen recognition by human γδ T-cells. Immunol. Rev. 2020;00:1–19. http://dx.doi.org/10.1111/imr.12919 

    An Update on the Molecular Basis of Phosphoantigen Recognition by Vγ9Vδ2 T Cells.
    Herrmann T, Fichtner AS, Karunakaran MM. Cells. 2020 Jun 9;9(6):E1433. 10.3390/cells9061433  

    Herrmann T. The Vg9Vd2 T Cell Antigen Receptor and Butyrophilin-3 A1: Models of Interaction, the Possibility of Co-Evolution, and the Case of Dendritic Epidermal T Cells. Front Immunol. 2014 Dec 19;5:648.eCollection

    Hünig T, Torres-Nagel N, Mehling B, Park HJ, Herrmann T. Thymic development and repertoire selection: the rat perspective. Immunol Rev. 2001 Dec;184:7-19.

    Herrmann T, MacDonald HR. The CD8 T cell response to staphylococcal enterotoxins. Semin Immunol. 1993 Feb;5(1):33-9.

    Publikationen in PubMed: