Deutsch Intern
    Institute for Virology and Immunobiology

    Selected publications

    Karunakaran MM, Willcox CR, Salim M, Paletta D, Fichtner AS , Noll A, Starick L, Nöhren A, Begley CR, Berwick KA, Chaleil RAG, Pitard V, Dechanet-Merville J, Bates PA, Kimmel B, Knowles,9 TJ Kunzmann V,Walter L, Jeeves M,Mohammed F, Willcox BE, Herrmann T. Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing. Immunity, 2020 March 17 52, 1–12. doi.org/10.1016/j.immuni.2020.02.014

    Fichtner AS, Karunakaran MM, Gu S, Boughter CT, Borowska MT, Starick L, Nöhren A, Göbel TW, Adams EJ, Herrmann T. Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6697-6707. https://doi.org/10.1073/pnas.1909474117. Epub 2020 Mar 5.

    Fichtner AS, Karunakaran MM, Starick L, Truman RW, Herrmann T. The Armadillo (Dasypus novemcinctus): A Witness but Not a Functional Example for the Emergence of the Butyrophilin 3/Vγ9Vδ2 System in Placental Mammals.Front Immunol. 2018 Feb 23;9:265. doi: 10.3389/fimmu.2018.00265. eCollection 2018

    Starick L, Riano F, Karunakaran MM, Kunzmann V, Li J, Kreiss M, Amslinger S, Scotet E, Olive D, De Libero G, Herrmann T. Butyrophilin 3A (BTN3A, CD277)-specific antibody 20.1 differentially activates Vg9Vd2 TCR clonotypes and interferes with phosphoantigen activation. Eur J Immunol. 2017 Jun;47(6):982-992. doi: 10.1002/eji.201646818. Epub 2017 Apr 27.

    Monzón-Casanova E, Rudolf R, Starick L, Müller I, Söllner C, Müller N, Westphal N, Miyoshi-Akiyama T, Uchiyama T, Berberich I, Walter L, Herrmann T. The Forgotten: Identification and Functional Characterization of MHC Class II Molecules H2-Eb2 and RT1-Db2. J Immunol. 2016 Feb 1K 196(3):988-99.

    Paletta D, Fichtner AS, Hahn AM, Starick L, Beyersdorf N, Monzon-Casanova E, Mueller TD, Herrmann T. The hypervariable region 4 (HV4) and position 93 of the a chain modulate CD1d-glycolipid binding of iNKT TCRs. Eur J Immunol. 2015 Apr 21. doi: 10.1002/eji.201545534. [Epub ahead of print]

    Riaño F, Karunakaran MM, Starick L, Li J, Scholz CJ, Kunzmann V, Olive D, Amslinger S, Herrmann T. Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6. Eur J Immunol. 2014 Sep;44(9):2571-6. doi: 10.1002/eji.201444712. Epub 2014 Jun 30.

    Karunakaran MM, Göbel TW, Starick L, Walter L, Herrmann T. Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos). Immunogenetics. 2014 Apr;66(4):243-54.

    Monzon-Casanova E, Paletta D, Starick L, Müller I, Sant'Angelo DB, Pyz E, Herrmann T. Direct identification of rat iNKT cells reveals remarkable similarities to human iNKT cells and a profound deficiency in LEW rats. Eur J Immunol. 2013 Feb;43(2):404-15.

    Harly C, Guillaume Y, Nedellec S, Peigné CM, Mönkkönen H, Mönkkönen J, Li J, Kuball J, Adams EJ, Netzer S, Déchanet-Merville J, Léger A, Herrmann T, Breathnach R, Olive D, Bonneville M, Scotet E. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gd T-cell subset. Blood. 2012 Sep 13;120(11):2269-79. doi: 10.1182/blood-2012-05-430470. Epub 2012 Jul 5.

    Monzon-Casanova E, Steiniger B, Schweigle S, Clemen H, Zdzieblo D, Starick L, Müller I, Wang CR, Rhost S, Cardell S, Pyz E, Herrmann T. CD1d expression in paneth cells and rat exocrine pancreas revealed by novel monoclonal antibodies which differentially affect NKT cell activation. PLOS One. 2010 Sep 30;5(9). pii: e13089.

    Li J, Herold MJ, Kimmel B, Müller I, Rincon-Orozco B, Kunzmann V, Herrmann T. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. J Immunol. 2009 Jun 15;182(12):8118-24.

    Pyz E, Naidenko O, Miyake S, Yamamura T, Berberich I, Cardell S, Kronenberg M, Herrmann T. The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR. J. Immunol. 2006 Jun 15;176(12):7447-55.

    Rincon-Orozco B, Kunzmann V, Wrobel P, Kabelitz D, Steinle A, Herrmann T. Activation of V gamma 9V delta 2 T cells by NKG2D. J Immunol. 2005 Aug 15;175(4):2144-51.

    Selected reviews:

    Butyrophiline: Verwandte der B7-Familie, γδ-T-Zellrezeptorliganden und vieles mehr. Herrmann T.  Trillium Immunologie 2/2021 https://doi.org/10.47184/ti.2021.02.04

    Immuno-antibiotics: Targeting microbial metabolic pathways sensed by uncvvonventional T cells. Eberl M, Oldfield E, Herrmann T. Immunotherapy Advances, Volume 1, Issue 1 ltab005, https://doi.org/10.1093/immadv/ltab005

    Herrmann T, Karunakaran MM, Fichtner AS. A glance over the fence: Using phylogeny and species comparison for a better understanding of antigen recognition by human γδ T-cells. Immunol. Rev. 2020;00:1–19. http://dx.doi.org/10.1111/imr.12919 

    An Update on the Molecular Basis of Phosphoantigen Recognition by Vγ9Vδ2 T Cells.
    Herrmann T, Fichtner AS, Karunakaran MM. Cells. 2020 Jun 9;9(6):E1433. 10.3390/cells9061433  

    Herrmann T. The Vg9Vd2 T Cell Antigen Receptor and Butyrophilin-3 A1: Models of Interaction, the Possibility of Co-Evolution, and the Case of Dendritic Epidermal T Cells. Front Immunol. 2014 Dec 19;5:648.eCollection

    Hünig T, Torres-Nagel N, Mehling B, Park HJ, Herrmann T. Thymic development and repertoire selection: the rat perspective. Immunol Rev. 2001 Dec;184:7-19.

    Herrmann T, MacDonald HR. The CD8 T cell response to staphylococcal enterotoxins. Semin Immunol. 1993 Feb;5(1):33-9.

    Publications in PubMed: