Deutsch Intern
Institute for Virology and Immunobiology

Selected publications

Always the newest on:



Nono JK, Lutz MB*, Brehm K*. Expansion of Host Regulatory T Cells by Secreted Products of the Tapeworm Echinococcus multilocularis. Front Immunol. 2020 May 8;11:798. *equal contribution

Ashour D, Arampatzi P, Pavlovic V, Förstner KU, Kaisho T, Beilhack A, Erhard F, Lutz MB. IL-12 from endogenous cDC1, and not vaccine DC, is required for Th1 induction. JCI Insight. 2020 May 21;5(10):e135143.

Dorhoi A, Kotzé LA, Berzofsky JA, Sui Y, Gabrilovich DI, Garg A, Hafner R, Khader SA, Schaible UE, Kaufmann SH, Walzl G, Lutz MB, Mahon RN, Ostrand-Rosenberg S, Bishai W, du Plessis N. Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus. J Clin Invest. 2020 Jun 1;130(6):2789-2799.

Kotzé LA, Young C, Leukes VN, John V, Fang Z, Walzl G, Lutz MB, du Plessis N.  Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts. EBioMedicine. 2020 Mar;53:102670.



John V, Kotze LA, Ribechini E, Walzl G, Du Plessis N, Lutz MB.  Caveolin-1 Controls Vesicular TLR2 Expression, p38 Signaling and T Cell Suppression in BCG Infected Murine Monocytic Myeloid-Derived Suppressor Cells. Front Immunol. 2019 Dec 3;10:2826.

Ribechini E, Eckert I, Beilhack A, Du Plessis N, Walzl G, Schleicher U, Ritter U, Lutz MB. Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cell-killing capability. JCI Insight. 2019 Jun 4;5(13):e128664.



Schierer S, Ostalecki C, Zinser E, Lamprecht R, Plosnita B, Stich L, Dörrie J, Lutz MB, Schuler G, Baur AS. Extracellular vesicles from mature dendritic cells (DC) differentiate monocytes into immature DC. Life Sci Alliance. 2018 Dec 3;1(6):e201800093.

Lohr, M., B. Freitag, A. Technau, J. Krauss, C. M. Monoranu, J. Rachor, M. B. Lutz, C. Hagemann, A. F. Kessler, T. Linsenmann, M. Wolfl, R. I. Ernestus, S. Engelhardt, G. Gelbrich, P. G. Schlegel, and M. Eyrich. 2018. High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion. Cancer immunology, immunotherapy : CII.

Vendelova, E., D. Ashour, P. Blank, F. Erhard, A. E. Saliba, U. Kalinke, and M. B. Lutz. 2018. Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells. Front Immunol 9: 333.

Riquelme, P., J. Haarer, A. Kammler, L. Walter, S. Tomiuk, N. Ahrens, A. K. Wege, I. Goecze, D. Zecher, B. Banas, R. Spang, F. Fandrich, M. B. Lutz, B. Sawitzki, H. J. Schlitt, J. Ochando, E. K. Geissler, and J. A. Hutchinson. 2018. TIGIT(+) iTregs elicited by human regulatory macrophages control T cell immunity. Nature communications 9: 2858.



Silva-Vilches, C., K. Pletinckx, M. Lohnert, V. Pavlovic, D. Ashour, V. John, E. Vendelova, S. Kneitz, J. Zhou, R. Chen, T. Reinheckel, T. D. Mueller, J. Bodem, and M. B. Lutz. 2017. Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion. PloS one 12: e0178114.

Ribechini, E., J. A. Hutchinson, S. Hergovits, M. Heuer, J. Lucas, U. Schleicher, A. L. Jordan Garrote, S. J. Potter, P. Riquelme, H. Brackmann, N. Muller, H. Raifer, I. Berberich, M. Huber, A. Beilhack, M. Lohoff, C. Bogdan, M. Eyrich, H. M. Hermanns, E. K. Geissler, and M. B. Lutz. 2017. Novel GM-CSF signals via IFN-gammaR/IRF-1 and AKT/mTOR license monocytes for suppressor function. Blood Adv 1: 947-960.

Lutz, M. B., H. Strobl, G. Schuler, and N. Romani. 2017. GM-CSF Monocyte-Derived Cells and Langerhans Cells As Part of the Dendritic Cell Family. Front Immunol 8: 1388.

Hellmann, A. M., J. Lother, S. Wurster, M. B. Lutz, A. L. Schmitt, C. O. Morton, M. Eyrich, K. Czakai, H. Einsele, and J. Loeffler. 2017. Human and Murine Innate Immune Cell Populations Display Common and Distinct Response Patterns during Their In Vitro Interaction with the Pathogenic Mold Aspergillus fumigatus. Front Immunol 8: 1716.

Du Plessis, N., R. Jacobs, A. Gutschmidt, Z. Fang, P. D. van Helden, M. B. Lutz, A. C. Hesseling, and G. Walzl. 2017. Phenotypically resembling myeloid derived suppressor cells are increased in children with HIV and exposed/infected with Mycobacterium tuberculosis. Eur J Immunol 47: 107-118.

Dohler, A., T. Schneider, I. Eckert, E. Ribechini, N. Andreas, M. Riemann, B. Reizis, F. Weih, and M. B. Lutz. 2017. RelB(+) Steady-State Migratory Dendritic Cells Control the Peripheral Pool of the Natural Foxp3(+) Regulatory T Cells. Front Immunol 8: 726.



Vendelova, E., Hrckova, G., Lutz, M. B., Brehm, K. and Nono Komguep, J., In vitro culture of Mesocestoides corti metacestodes and isolation of immunomodulatory excretory-secretory products. (2016) Parasite Immunol. 38: 403-413.

Vendelova, E., Camargo de Lima, J., Lorenzatto, K. R., Monteiro, K. M., Mueller, T., Veepaschit, J., Grimm, C., Brehm, K., Hrckova, G., Lutz, M. B., Ferreira, H. B. and Nono, J. K., Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions. (2016) PLoS Negl Trop Dis. 10: e0005061.

Montalban Del Barrio, I., Penski, C., Schlahsa, L., Stein, R. G., Diessner, J., Wockel, A., Dietl, J., Lutz, M. B., Mittelbronn, M., Wischhusen, J. and Hausler, S. F., Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages - a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape. (2016) J Immunother Cancer. 4: 49.

Chopra, M., Biehl, M., Steinfatt, T., Brandl, A., Kums, J., Amich, J., Vaeth, M., Kuen, J., Holtappels, R., Podlech, J., Mottok, A., Kraus, S., Jordan-Garrote, A. L., Bauerlein, C. A., Brede, C., Ribechini, E., Fick, A., Seher, A., Polz, J., Ottmuller, K. J., Baker, J., Nishikii, H., Ritz, M., Mattenheimer, K., Schwinn, S., Winter, T., Schafer, V., Krappmann, S., Einsele, H., Muller, T. D., Reddehase, M. J., Lutz, M. B., Mannel, D. N., Berberich-Siebelt, F., Wajant, H. and Beilhack, A., (2016) Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion. J Exp Med 213: 1881-1900.

Lutz, M. B. (2016). Induction of CD4 +Regulatory and Polarized Effector/helper T Cells by Dendritic Cells. Immune Network, 16(1), 13.


Lutz, M. B., K. Inaba, G. Schuler, and N. Romani (2016) Still Alive and Kicking: In-Vitro-Generated GM-CSF Dendritic Cells! Immunity 44: 1-2.

Groh, J., E. Ribechini, D. Stadler, T. Schilling, M. B. Lutz, and R. Martini (2016) Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease. Glia. Jan 17. doi: 10.1002/glia.22962. [Epub ahead of print]



Chaudhari, S.M., J.C. Sluimer, M. Koch, T.L. Theelen, H.D. Manthey, M. Busch, C. Caballero-Franco, F. Vogel, C. Cochain, J. Pelisek, M.J. Daemen, M.B. Lutz, A. Gorlach, S. Kissler, H.M. Hermanns, and A. Zernecke. (2015) Deficiency of HIF1alpha in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology 35:2316-2325.

Messmann, J.J., T. Reisser, F. Leithauser, M.B. Lutz, K.M. Debatin, and G. Strauss. (2015) In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity. Blood 126:1138-1148.

Milanez-Almeida, P., T. Ulas, M. Pasztoi, S. Glage, K. Schughart, M.B. Lutz, J.L. Schultze, and J. Huehn. (2015) CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. European Journal of Microbiology & Immunology 5:246-255.

Pletinckx, K., M. Vaeth, T. Schneider, N. Beyersdorf, T. Hunig, F. Berberich-Siebelt, and M.B. Lutz. (2015) Immature dendritic cells convert anergic nonregulatory T cells into Foxp3- IL-10+ regulatory T cells by engaging CD28 and CTLA-4. Eur. J. Immunol. 45:480-491.

Vendelova, E., M.B. Lutz, and G. Hrckova. (2015) Immunity and immune modulation elicited by the larval cestode Mesocestoides vogae and its products. Parasite Immunology Jul 27. doi: 10.1111/pim.12216. [Epub ahead of print]:

Vogel, S.Z., S. Schlickeiser, K. Jurchott, L. Akyuez, J. Schumann, C. Appelt, K. Vogt, M. Schroder, M. Vaeth, F. Berberich-Siebelt, M.B. Lutz, G. Grutz, and B. Sawitzki. (2015) TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production. J Immunol 194:3136-3146.



Pletinckx, K., Vaeth, M., Schneider, T., Beyersdorf, N., Hunig, T., Berberich-Siebelt, F., and Lutz, M.B. (2014). Immature dendritic cells convert anergic non-regulatory T cells into Foxp3 IL-10 regulatory T cells by engaging CD28 and CTLA-4. European journal of immunology.

Nono, J.K., Lutz, M.B., and Brehm, K. (2014). EmTIP, a T-Cell Immunomodulatory Protein Secreted by the Tapeworm Echinococcus multilocularis Is Important for Early Metacestode Development. PLoS Negl Trop Dis 8, e2632.



Pletinckx, K., and M. B. Lutz. (2013) Dendritic cells generated with Flt3L and exposed to apoptotic cells lack induction of T cell anergy and Foxp3 regulatory T cell conversion in vitro. Immunobiology. 2013 Oct 24. [Epub ahead of print]

Heuer, M., A. S. Behlich, J. S. Lee, E. Ribechini, E. K. Jo, and M. B. Lutz. (2013) The 30-kDa and 38-kDa antigens from Mycobacterium tuberculosis induce partial maturation of human dendritic cells shifting CD4(+) T cell responses towards IL-4 production. BMC Immunol 14: 48.

Baur, A.S., *, Lutz, M.B., *, Schierer, S., Beltrame, L., Theiner, G., Zinser, E., Ostalecki, C., Heidkamp, G., Haendle, I., Erdmann, M., Wiesinger, M., Leisgang, W., Gross, S., Pommer, A.J., Kämpgen, E., Dudziak, D., Steinkasserer, A., Cavalieri, D., Schuler-Thurner, B., and Schuler, G. (2013). Denileukin diftitox (ONTAK) induces a tolerogenic phenotype in Dendritic Cells and stimulates survival of resting Treg. Blood 122, 2185-94    * equal contributions.

du Plessis, N., Loebenberg, L., Kriel, M., von Groote-Bidlingmaier, F., Ribechini, E., Loxton, A.G., van Helden, P.D., Lutz, M.B., and Walzl, G. (2013). Myeloid Derived Suppressor Cells Accumulate and Suppress T Cell Function during Active Tuberculosis and Following Recent Mycobacterium Tuberculosis Infection. Am J Respir Crit Care Med 188, 724-32.

Granucci, F., Lutz, M.B., and Zanoni, I. (2013). The nature of activatory and tolerogenic dendritic cell-derived signal 2. Front. Immunol. 4, Article 198.

Lutz, M.B. (2013). How quantitative differences in dendritic cell maturation can direct T1/T2-cell polarization. Oncoimmunology 2, e22796.

Koutsilieri, E., Lutz, M.B., and Scheller, C. (2013). Autoimmunity, dendritic cells and relevance for Parkinson's disease. J Neural Transm 120, 75-81.



Langenhorst, D., Gogishvili, T., Ribechini, E., Kneitz, S., McPherson, K., Lutz, M.B., and Hunig, T. (2012). Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells. PLoS One 7, e50080.

Lutz, M.B. (2012a). Buy one, get one free: additional functions of GM-CSF in DC maturation. European journal of immunology 42, 35-38.

Lutz, M.B. (2012b). Therapeutic potential of semi-mature dendritic cells for tolerance induction. Front Immunol 3, 123.

Nono, J.K., Pletinckx, K., Lutz, M.B., and Brehm, K. (2012). Excretory/Secretory-Products of Echinococcus multilocularis Larvae Induce Apoptosis and Tolerogenic Properties in Dendritic Cells In Vitro. PLoS Negl Trop Dis 6, e1516.



Azukizawa, H., Dohler, A., Kanazawa, N., Nayak, A., Lipp, M., Malissen, B., Autenrieth, I., Katayama, I., Riemann, M., Weih, F., Berberich-Siebelt, F., and Lutz, M.B. (2011). Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells. Eur. J. Immunol. 41, 1420-1434.

Oberlander, U., Pletinckx, K., Dohler, A., Muller, N., Lutz, M.B., Arzberger, T., Riederer, P., Gerlach, M., Koutsilieri, E., and Scheller, C. (2011). Neuromelanin is an immune stimulator for dendritic cells in vitro. BMC Neurosci 12, 116.

Pletinckx, K., Döhler, A., Pavlovic, V., and Lutz, M.B. (2011a). Role of dendritic cell maturity/costimulation for generation, homeostasis and suppressive activity of regulatory T cells. Frontiers in Immunology 2 (article 39) 1-15.

Pletinckx, K., Stijlemans, B., Pavlovic, V., Laube, R., Brandl, C., Kneitz, S., Beschin, A., De Baetselier, P., and Lutz, M.B. (2011b). Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses. Eur. J. Immunol. 41, 3479-3494.

Weber, C., Meiler, S., Doring, Y., Koch, M., Drechsler, M., Megens, R.T., Rowinska, Z., Bidzhekov, K., Fecher, C., Ribechini, E., van Zandvoort, M.A., Binder, C.J., Jelinek, I., Hristov, M., Boon, L., Jung, S., Korn, T., Lutz, M.B., Forster, I., Zenke, M., Hieronymus, T., Junt, T., and Zernecke, A. (2011). CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest 121, 2898-2910.



Brandl, C., Ortler, S., Herrmann, T., Cardell, S., Lutz, M.B., and Wiendl, H. (2010). B7-H1-deficiency enhances the potential of tolerogenic dendritic cells by activating CD1d-restricted type II NKT cells. PLoS One 5, e10800.

Lutz, M.B., Dohler, A., and Azukizawa, H. (2010). Revisiting the tolerogenicity of epidermal Langerhans cells. Immunol Cell Biol 88, 381-386.

Ribechini, E., Greifenberg, V., Sandwick, S., and Lutz, M.B. (2010). Subsets, expansion and activation of myeloid-derived suppressor cells. Med Microbiol Immunol 199, 273-281.

Schumann, K., Lammermann, T., Bruckner, M., Legler, D.F., Polleux, J., Spatz, J.P., Schuler, G., Forster, R., Lutz, M.B., Sorokin, L., and Sixt, M. (2010). Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity 32, 703-713.

Ziegler-Heitbrock, L., Ancuta, P., Crowe, S., Dalod, M., Grau, V., Hart, D.N., Leenen, P.J., Liu, Y.J., MacPherson, G., Randolph, G.J., Scherberich, J., Schmitz, J., Shortman, K., Sozzani, S., Strobl, H., Zembala, M., Austyn, J.M., and Lutz, M.B. (2010). Nomenclature of monocytes and dendritic cells in blood. Blood 116, e74-80.



Berger, T.G., Schulze-Koops, H., Schafer, M., Muller, E., and Lutz, M.B. (2009). Immature and maturation-resistant human dendritic cells generated from bone marrow require two stimulations to induce T cell anergy in vitro. PLoS One 4, e6645.

Greifenberg, V., Ribechini, E., Rossner, S., and Lutz, M.B. (2009). Myeloid-derived suppressor cell activation by combined LPS and IFN-gamma treatment impairs DC development. Eur. J. Immunol. 39, 2865-2876.

Lutz, M.B., and Kurts, C. (2009). Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells. Eur. J. Immunol. 39, 2325-2330.

Ribechini, E., Leenen, P.J., and Lutz, M.B. (2009). Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloid-derived suppressor cell activity in BM cells. Eur. J. Immunol. 39, 3538-3551.



Dietze, B., Cierpka, E., Schafer, M., Schill, W., and Lutz, M.B. (2008). An improved method to generate equine dendritic cells from peripheral blood mononuclear cells: Divergent maturation programs by IL-4 and LPS. Immunobiology 213, 751-758.

Goldwich, A., Hahn, S.S., Schreiber, S., Meier, S., Kampgen, E., Wagner, R., Lutz, M.B., and Schubert, U. (2008). Targeting HIV-1 Gag into the defective ribosomal product pathway enhances MHC class I antigen presentation and CD8+ T cell activation. J Immunol 180, 372-382.

Hänig, J., and Lutz, M.B. (2008). Suppression of mature dendritic cell function by regulatory T cells in vivo is abrogated by CD40 licensing. J. Immunol. 180, 1405-1413.

Lutz, M.B., and Rößner, S. (2008). Factors influencing the generation of murine dendritic cells from bone marrow: The special role of fetal calf serum. Immunobiology 212, 855-862.

Rößner, S., Zinser, E., Menges, M., Wiethe, C., Littmann, L., Hänig, J., Steinkasserer, A., and Lutz, M.B. (2008). Minor role of bystander tolerance to fetal calf serum in a peptide-specific dendritic cell vaccine model against autoimmunity: comparison with serum-free cultures. J Immunother 31, 656-664.


Theiner, G., Rößner, S., Dalpke, A., Bode, K., Berger, T., Gessner, A., and Lutz, M.B. (2008). TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells. Mol Immunol 45, 244-252.

Wiethe, C., Debus, A., Mohrs, M., Steinkasserer, A., Lutz, M.B.*, and Gessner, A. (2008). Dendritic cell differentiation state and their interaction with NKT cells determine Th1/Th2 differentiation in the murine model of Leishmania major infection. J Immunol 180, 4371-4381 *equal contribution with last author



Lutz, M.B. (2007). The role of dendritic cell migration for the induction of immunity and the maintenance of tolerance. In Antigen-presenting cells and the eye, M. Zierhut, H.G. Rammensee, and J.W. Streilein, eds. (New York: Informa Healthcare), pp. 27-36.


Lutz, M.B., and Rossner, S. (2007). Factors influencing the generation of murine dendritic cells from bone marrow: the special role of fetal calf serum. Immunobiology 212, 855-862.

Siegemund, S., Schutze, N., Freudenberg, M.A., Lutz, M.B., Straubinger, R.K., and Alber, G. (2007). Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis. Immunobiology 212, 739-750.

Waithman, J., Allan, R.S., Kosaka, H., Azukizawa, H., Shortman, K., Lutz, M.B., Heath, W.R., Carbone, F.R., and Belz, G.T. (2007). Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells. J. Immunol. 179, 4535-4541.

Wiethe, C., Schiemann, M., Busch, D., Haeberle, L., Kopf, M., Schuler, G., and Lutz, M.B. (2007). Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity. J Immunol 178, 4908-4916.



Baumjohann, D., Hess, A., Budinsky, L., Brune, K., Schuler, G., and Lutz, M.B. (2006). In vivo magnetic resonance imaging of dendritic cell migration into the draining lymph nodes of mice. European journal of immunology 36, 2544-2555.

Baumjohann, D., and Lutz, M.B. (2006). Non-invasive imaging of dendritic cell migration in vivo. Immunobiology 211, 587-597.

Frick, J.S., Zahir, N., Muller, M., Kahl, F., Bechtold, O., Lutz, M.B., Kirschning, C.J., Reimann, J., Jilge, B., Bohn, E., and Autenrieth, I.B. (2006). Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: an important role for IL-6. European journal of immunology 36, 1537-1547.

Lutz, M.B. (2006). Differentiation stages and subsets of tolerogenic dendritic cells. In Handbook of Dendritic Cells. Biology, Diseases and Therapy, M.B. Lutz, N. Romani, and A. Steinkasserer, eds. (Weinheim: VCH-Wiley), pp. 517-543.


Voigtländer, C., Rößner, S., Cierpka, E., Theiner, G., Wiethe, C., Menges, M., Schuler, G., and Lutz, M.B. (2006). Dendritic cells matured with TNF can be further activated in vitro and after subcutaneous injection in vivo which converts their tolerogenicity into immunogenicity. J Immunother 29, 407-415.

Theiner, G., Gessner, A., and Lutz, M.B. (2006). The mast cell mediator PGD2 suppresses IL-12 release by dendritic cells leading to Th2 polarized immune responses in vivo. Immunobiology 211, 463-472.



Kleindienst, P., Wiethe, C., Lutz, M.B., and Brocker, T. (2005). Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells. J Immunol 174, 3941-3947 (*equal contribution with last author).

Menges, M., Baumeister, T., Rößner, S., Stoitzner, P., Romani, N., Gessner, A., and Lutz, M.B. (2005). IL-4 supports the generation of a dendritic cell subset from murine bone marrow with altered endocytosis capacity. J Leukoc Biol 77, 535-543.

Rößner, S., Voigtländer, C., Wiethe, C., Hänig, J., Seifarth, C., and Lutz, M.B. (2005). Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro. Eur. J. Immunol. 35, 3533-3544.

Sixt, M., Kanazawa, N., Selg, M., Samson, T., Roos, G., Reinhardt, D.P., Pabst, R., Lutz, M.B., and Sorokin, L. (2005). The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity 22, 19-29.



Kanazawa, N., Tashiro, K., Inaba, K., Lutz, M.B., and Miyachi, Y. (2004). Molecular Cloning of Human Dectin-2. J. Invest. Dermatol. 122, 1522-1524.

Lutz, M.B. (2004). IL-3 in dendritic cell development and function. A comparison with GM-CSF and IL-4. Immunobiology 209, 79-87.

Lutz, M.B., Berger, T., Schultz, E.S., and Steinkasserer, A. (2004). Dendritic Cells. In Encyclopedia of molecular cell biology and molecular medicine, R.A. Meyers, ed. (Weinheim: Wiley-VHC), pp. 213-237.

Zinser, E., Lechmann, M., Golka, A., Lutz, M.B., and Steinkasserer, A. (2004). Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83. The Journal of experimental medicine 200, 345-351.



Baumeister, T., Rossner, S., Pech, G., de Bruijn, M.F., Leenen, P.J., Schuler, G., and Lutz, M.B. (2003). Interleukin-3Ralpha+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3. J Invest Dermatol 121, 280-288.

Lutz, M.B. (2003a). Aufrechterhaltung der immunologischen Toleranz zur Vermeidung von Autoimmunität. Die Rolle dendritischer Zellen. Hautarzt 54, 894-896.

Lutz, M.B. (2003b). [Preservation of immune tolerance to avoid autoimmunity. The role of dendritic cells]. Hautarzt 54, 894-896.

Nikolic, T., de Bruijn, M.F., Lutz, M.B., and Leenen, P.J. (2003). Developmental stages of myeloid dendritic cells in mouse bone marrow. Int Immunol 15, 515-524.

Verdoodt, B., Blazek, T., Rauch, P., Schuler, G., Steinkasserer, A., Lutz, M.B., and Funk, J.O. (2003). The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 are not essential in T cell anergy. European journal of immunology 33, 3154-3163.



Dieckmann, D., Bruett, C.H., Ploettner, H., Lutz, M.B., and Schuler, G. (2002). Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. The Journal of experimental medicine 196, 247-253.

Lutz, M.B., Schnare, M., Menges, M., Rossner, S., Rollinghoff, M., Schuler, G., and Gessner, A. (2002). Differential functions of IL-4 receptor types I and II for dendritic cell maturation and IL-12 production and their dependency on GM-CSF. J Immunol 169, 3574-3580.

Lutz, M.B., and Schuler, G. (2002). Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol 23, 445-449.

Menges, M., Rossner, S., Voigtlander, C., Schindler, H., Kukutsch, N.A., Bogdan, C., Erb, K., Schuler, G., and Lutz, M.B. (2002). Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. The Journal of experimental medicine 195, 15-21.

Ratzinger, G., Stoitzner, P., Ebner, S., Lutz, M.B., Layton, G.T., Rainer, C., Senior, R.M., Shipley, J.M., Fritsch, P., Schuler, G., and Romani, N. (2002). Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin. J Immunol 168, 4361-4371.



Funk, J.O., and Lutz, M.B. (2001). Neue Funktionen von Tumor-Nekrose-Faktor-Rezeptoren auf Dendritischen Zellen. Immunologie Aktuell 2, 56-57.


Schindler, H., Lutz, M.B., Röllinghoff, M., and Bogdan, C. (2001). The production of Interferon-g by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J. Immunol. 166, 3075-3082.


Funk, J.O., Walczak, H., Voigtlander, C., Berchtold, S., Baumeister, T., Rauch, P., Rossner, S., Steinkasserer, A., Schuler, G., and Lutz, M.B. (2000). Cutting edge: resistance to apoptosis and continuous proliferation of dendritic cells deficient for TNF receptor-1. J Immunol 165, 4792-4796.

Kukutsch, N.A., Rößner, S., Schuler, G., Austyn, J.M., and Lutz, M.B. (2000). Formation and kinetics of MHC class I/Peptide complexes on murine dendritic cells. J. Invest. Dermatol. 115, 449-453.

Lutz, M.B. (2000). T-Zell-Toleranz durch unreife Dendritische Zellen und die neue Rolle von IL-4 als indirektes T-Helfer-Typ 1 Zytokin. Immunologie Aktuell 1, 54-55.

Lutz, M.B., Kukutsch, N.A., Menges, M., Rossner, S., and Schuler, G. (2000a). Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro. European journal of immunology 30, 1048-1052.

Lutz, M.B., Suri, R.M., Niimi, M., Ogilvie, A.L., Kukutsch, N.A., Rossner, S., Schuler, G., and Austyn, J.M. (2000b). Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. European journal of immunology 30, 1813-1822.



Lutz, M.B., Kukutsch, N., Ogilvie, A.L., Rossner, S., Koch, F., Romani, N., and Schuler, G. (1999). An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223, 77-92.

Schuler, G., Lutz, M.B., Bender, A., Thurner, B., Röder, C., Young, J., and Romani, N. (1999). A guide to the isolation and propagation of dendritic cells. In Dendritic Cells: Biology and Clinical Applications, M.T. Lotze, and A.W. Thomson, eds. (San Diego: Academic Press Ltd.), pp. 515-533.


Stoitzner, P., Zanella, M., Ortner, U., Lukas, M., Tagwerker, A., Janke, K., Lutz, M.B., Schuler, G., Echtenacher, B., Ryffel, B., Koch, F., and Romani, N. (1999). Migration of langerhans cells and dermal dendritic cells in skin organ cultures: augmentation by TNF-alpha and IL-1beta. J Leukoc Biol 66, 462-470.