English Intern
    Institut für Virologie und Immunbiologie


    Avota link pubmed: https://pubmed.ncbi.nlm.nih.gov/?term=Avota+Elita


    Selected articles:


    1. Neutral sphingomyelinase-2 (NSM29 controls T cell metabolic homeostasis

        and reprogramming during activation.  De Lira MN, Raman SJ, Schulze A,

        Schneider-Schaulies S, Avota E.  Front Mol Biosci 2020 Sep 4;7:217.

        doi: 10.3389/fmolb.2020.00217.


    2. Role of neutral sphingomyelinase-2 (NSM2) in the control of T cell plasma

        membrane lipid composition and cholesterol homeostasis. Börtlein C,

        Schumacher F, Kleuser B, Dölken L, Avota E. Front Cell Dev Biol 2019 Oct 15.

        doi: 10.3389/fcell.2019.00226.


    3. The neutral sphingomyelinase 2 is required to polarize and sustain T cell

         receptor signaling. Börtlein C, Draeger A, Schoenauer R, Kuhlemann A,

         Sauer M, Schneider-Schaulies S, Avota E. Front Immunol 2018 Apr 18.

         doi: 10.3389/fimmu.2018.00815.


    4. The neutral sphingomyelinase 2 in in T cell receptor signaling and polarity.

         Collenburg L, Schneider-Schaulies S, Avota E. Biological Chemistry 2018 Feb 2.



    5. The activity of the neutral sphingomyelinase is important in T cell

         recruitment and directional migration. Collenburg L, Beyersdorf N, Wiese T,

         Arenz C, Saeid E, Becker-Fliger A, Schneider-Schaulies S, Avota E.

         Front Immunol 2017 Aug 21;8:1007. doi: 10.3389/fimmu.2017.01007.   


    6. Inhibition of acid sphingomyelinase allows for selective targeting of CD4+

         conventional versus FoxP3+ regulatory T cells. Hollmann C, Werner S,

         Avota E, Reuter D, Japtok L, Kleuser B, Gulbins E, Becker KA, Scneider-

         Schaulies J, Beyersdorf N. J Immunol 2016 Okt 15,197(8):3130-3141.

         doi: 10.4049/jimmunol.1600691.


    7. The role of the neutral sphingomyelinase in physiological and measles virus

        (MV) mediated T cell suppression. Mueller N, Avota E, Collenburg L, Gulbins E,

        Schneider-Schaulies S. PLoS Pathog 2014, Dec 18,10(12).

        doi: 10.1159/000362981.


    8. The role of sphingomyelin breakdown in measles virus immunomodulation.

         Avota E, Schneider-Schaulies S. Cell. Physiol. Biochem. 2014,34(1).

         doi: 10.1159/000362981.


    9.  DC-SIGN mediated sphingomyelinase activation and ceramide generation is

         essential for enhancement of viral uptake in dendritic cells. Avota E,

         Gulbins E, Schneider-Schaulies S. PLos Pathog. 2011, Feb 17,

         doi: 10.1371/journal.ppat.1001290


    10.Induction of membrane ceramide: a novel strategy to interfere with T  

         lymphocyte cytoskeletal reorganization in viral immunosuppression.

         Gassert E, Avota E, Harms H, Krohne G, Gulbins E. PLoS Pathog 2009,5(10).

         doi: 10.1371/journal.ppat.1000623




    RTG2581 Metabolism, topology and compartmentalization of membrane proximal lipid and signaling components in infection (Project 2: Measles virus dependent regulation of sphingolipids at the T cell plasma membrane and their differential role in effector and memory T cell function)