English Intern
Institut für Virologie und Immunbiologie


Avota link pubmed: https://pubmed.ncbi.nlm.nih.gov/?term=Avota+Elita


Selected articles:


1. Neutral sphingomyelinase-2 (NSM29 controls T cell metabolic homeostasis

    and reprogramming during activation.  De Lira MN, Raman SJ, Schulze A,

    Schneider-Schaulies S, Avota E.  Front Mol Biosci 2020 Sep 4;7:217.

    doi: 10.3389/fmolb.2020.00217.


2. Role of neutral sphingomyelinase-2 (NSM2) in the control of T cell plasma

    membrane lipid composition and cholesterol homeostasis. Börtlein C,

    Schumacher F, Kleuser B, Dölken L, Avota E. Front Cell Dev Biol 2019 Oct 15.

    doi: 10.3389/fcell.2019.00226.


3. The neutral sphingomyelinase 2 is required to polarize and sustain T cell

     receptor signaling. Börtlein C, Draeger A, Schoenauer R, Kuhlemann A,

     Sauer M, Schneider-Schaulies S, Avota E. Front Immunol 2018 Apr 18.

     doi: 10.3389/fimmu.2018.00815.


4. The neutral sphingomyelinase 2 in in T cell receptor signaling and polarity.

     Collenburg L, Schneider-Schaulies S, Avota E. Biological Chemistry 2018 Feb 2.



5. The activity of the neutral sphingomyelinase is important in T cell

     recruitment and directional migration. Collenburg L, Beyersdorf N, Wiese T,

     Arenz C, Saeid E, Becker-Fliger A, Schneider-Schaulies S, Avota E.

     Front Immunol 2017 Aug 21;8:1007. doi: 10.3389/fimmu.2017.01007.   


6. Inhibition of acid sphingomyelinase allows for selective targeting of CD4+

     conventional versus FoxP3+ regulatory T cells. Hollmann C, Werner S,

     Avota E, Reuter D, Japtok L, Kleuser B, Gulbins E, Becker KA, Scneider-

     Schaulies J, Beyersdorf N. J Immunol 2016 Okt 15,197(8):3130-3141.

     doi: 10.4049/jimmunol.1600691.


7. The role of the neutral sphingomyelinase in physiological and measles virus

    (MV) mediated T cell suppression. Mueller N, Avota E, Collenburg L, Gulbins E,

    Schneider-Schaulies S. PLoS Pathog 2014, Dec 18,10(12).

    doi: 10.1159/000362981.


8. The role of sphingomyelin breakdown in measles virus immunomodulation.

     Avota E, Schneider-Schaulies S. Cell. Physiol. Biochem. 2014,34(1).

     doi: 10.1159/000362981.


9.  DC-SIGN mediated sphingomyelinase activation and ceramide generation is

     essential for enhancement of viral uptake in dendritic cells. Avota E,

     Gulbins E, Schneider-Schaulies S. PLos Pathog. 2011, Feb 17,

     doi: 10.1371/journal.ppat.1001290


10.Induction of membrane ceramide: a novel strategy to interfere with T  

     lymphocyte cytoskeletal reorganization in viral immunosuppression.

     Gassert E, Avota E, Harms H, Krohne G, Gulbins E. PLoS Pathog 2009,5(10).

     doi: 10.1371/journal.ppat.1000623




RTG2581 Metabolism, topology and compartmentalization of membrane proximal lipid and signaling components in infection (Project 2: Measles virus dependent regulation of sphingolipids at the T cell plasma membrane and their differential role in effector and memory T cell function)