The group has a long standing interest in decephering virus-host interactions, mainly at the level of receptor interaction, membrane dynamics and membrane proximal signaling in T and professional antigenpresenting cells. Major research foci are:
1. The role of attachment and entry receptors in measles virus (MV) infection and transmission. In that context we specifically address MV uptake into professional antigen-presenting cells (focussing on dendritic and Langerhans cells) and subsequent transmission to conjugating T cells. Receptor signaling in response to MV interaction is also analyzed with regard to modulation of membrane sphingolipids and signaling pathways important in DC activation. This also includes analyses addressing the compromised ability of DCs exposed to or infected with MV to promote T cell activation. We have recently extended our analyses on receptor mediated regulation of DC activity by using envelope proteins of human endogenous retroviruses as effectors.