English Intern
    Institut für Virologie und Immunbiologie


    Original articles

    Plessis SD, Vink M, Joska JA, Koutsilieri E, Stein DJ, Emsley R (2014). HIV infection and the fronto-striatal system: a systematic review and meta-analysis of fMRI studies. AIDS 28: 803-811.


    Horn A, Scheller C, du Plessis S, Arendt G, Nolting T, Joska J, Sopper S, Maschke M, Obermann M, Husstedt IW, Hain J, Maponga T, Riederer P, Koutsilieri E (2013). Increases in CSF dopamine in HIV patients are due to the dopamine transporter 10/10-repeat allele which is more frequent in HIV-infected individuals. J Neural Transm 120: 1411-1419.


    Steinbrink F, Evers S, Buerke B, Young P, Arendt G, Koutsilieri E, Reichelt D, Lohmann H, Husstedt IW (2013). Cognitive impairment in HIV infection is associated with MRI and CSF pattern of neurodegeneration. Eur J Neurol 20: 420-428.


    Nolting T, Lindecke A, Hartung HP, Koutsilieri E, Maschke M, Husstedt IW, Sopper S, Stüve O, Arendt G (2012). Cytokine levels in CSF and neuropsychological performance in HIV patients. J Neurovirol 18:157-161.


    Kasang C, Ulmer A, Donhauser N, Schmidt B, Stich A, Klinker H, Kalluvya S, Koutsilieri E, Rethwilm A, Scheller C (2012) HIV patients treated with low-dose prednisolone exhibit lower immune activation than untreated patients. BMC Infect Dis 12: 14.


    Oberlander U, Pletinckx K, Dohler A, Muller N, Lutz MB, Arzberger T, Riederer P, Gerlach M, Koutsilieri E, Scheller C (2011) Neuromelanin is an immune stimulator for dendritic cells in vitro. BMC Neurosci 12: 116.


    Kasang C, Kalluvya S, Majinge C, Stich A, Bodem J, Kongola G, Jacobs GB, Mlewa M, Mildner M, Hensel I, Horn A, Preiser W, van Zyl G, Klinker H, Koutsilieri E, Rethwilm A, Scheller C, Weissbrich B (2011) HIV drug resistance (HIVDR) in antiretroviral therapy-naive patients in Tanzania not eligible for WHO threshold HIVDR survey is dramatically high. PLoS One 6: e23091.


    Bischoff T, Stahl-Hennig C, Mätz-Rensing K, Koutsilieri E, Sopper S (2011). Definition of leukocyte subsets in primate central nervous system by polychromatic flow cytometry. Cytometry 79: 436-445.


    Scheller C, Arendt G, Nolting T, Antke C, Sopper S, Maschke M, Obermann M, Angerer A, Husstedt IW, Meisner F, Neuen-Jacob E, Muller HW, Carey P, Ter Meulen V, Riederer P, Koutsilieri E (2010). Increased dopaminergic neurotransmission in therapy-naive asymptomatic HIV patients is not associated with adaptive changes at the dopaminergic synapses. J Neural Transm 117: 699-705.


    Nolting T, Lindecke A, Koutsilieri E, Maschke M, Husstedt IW, Sopper S, Stüve O, Hartung HP, Arendt G. (2010). Measurement of soluble inflammatory mediators in cerebrospinal fluid of human immunodeficiency virus-positive patients at distinct stages of infection by solid-phase protein array. J Neurovirol 15: 390-400.


    Obermann M, Küper M, Kastrup O, Yaldizli O, Esser S, Thiermann J, Koutsilieri E, Arendt G, Diener HC, Maschke M; German Competence Network HIV/AIDS (2009). Substantia nigra hyperechogenicity and CSF dopamine depletion in HIV. J Neurol. 256:948-953.


    Meisner F, Scheller C, Kneitz S, Sopper S, Neuen-Jacob E, Riederer P, ter Meulen V, Koutsilieri E (2008). Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: a novel pharmacological action of memantine. Neuropsychopharmacol  33: 2228-2236


    Meisner F, Neuen-Jacob E, Sopper S, Schmidt M, Schalmmes S, Scheller C, Vosswinkel D, ter Meulen V, Riederer P, Koutsilieri E (2008). Disruption of excitatory amino acid transporters in brains of SIV-infected rhesus macaques is associated with microglia activation. J Neurochem 104: 202-209


    Kneitz S, Meisner F, Sopper S, Kaiser F, Grünblatt E, Scheller C, Riederer P, ter Meulen V, Koutsilieri E (2007). Biostatistical analysis of gene microarrays reveal diverse expression clusters between macaque subspecies in brain SIV infection. J Neural Transm 72: 43-49


    Jacob CP, Koutsilieri E, Bartl J, Neuen-Jacob E, Arzberger T, Zander N, Ravid R, Roggendorf W, Riederer P, Grunblatt E (2007). Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease. J Alzheimers Dis 11:97-116


    Plochmann K, Korte G, Koutsilieri E, Richling E, Riederer P, Rethwilm A, Schreier P, Scheller C (2007). Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells. Arch Biochem Biophys 460:1-9


    Arendt G, Nolting T, Frisch C, Husstedt IW, Gregor N, Koutsilieri E, Maschke M, Angerer A, Obermann M, Neuen-Jacob E, Sopper S, Adams O, Loeffert S, Riederer P, ter Meulen V (2007). Intrathecal viral replication and cerebral deficits in different stages of HIV disease. J Neurovirol 13:225-232


    Grünblatt E, Koutsilieri E, Hoyer S, Riederer P (2006). Gene expression alterations in brain areas of intracerebroventricular streptozotocin-treated rat. J Alzheimer´s Dis 9: 261-271


    Scheller C, Knoferle J, Ullrich A, Prottengeier J, Racek T, Sopper S, Jassoy C, Rethwilm A, Koutsilieri E (2006). Caspase inhibition in apoptotic T cells triggers necrotic cell death depending on the cell type and the proapoptotic stimulus. J Cell Biochem 97: 1350-1361


    Scheller C, Sopper S, Jenuwein M, Neuen-Jacob E, Tatschner T, Grünblatt E, ter Meulen V, Riederer P, Koutsilieri E (2005). Early impairment in dopaminergic neurotransmission in brains of SIV-infected rhesus monkeys due to microglia activation. J Neurochem 95: 377-387


    Li J, Scheller C, Koutsilieri E, Griffiths F, Beart PM, Mercer LD, Halliday G, Kettle E, Rowe D, Riederer P, Gerlach M, Rodriguez M, Double KL. Differential effects of human neuromelanin and synthetic dopamine melanin on neuronal and glial cells (2005). J Neurochem 95: 599-608


    Grunblatt E, Schlosser R, Fischer P, Fischer MO, Li J, Koutsilieri E, Wichart I, Sterba N, Rujescu D, Moller HJ, Adamcyk W, Dittrich B, Muller F, Oberegger K, Gatterer G, Jellinger KJ, Mostafaie N, Jungwirth S, Huber K, Tragl KH, Danielczyk W, Riederer P (2005). Oxidative stress related markers in the "VITA" and the centenarian projects. Neurobiol Aging 26: 429-438


    Jenuwein M, Scheller C, Neuen-Jacob E, Sopper S, Tatschner T, ter Meulen V, Riederer P, Koutsilieri E (2004). Dopamine deficits and regulation of the cAMP second messenger system in brains of simian immunodeficiency virus-infected rhesus monkeys. J Neurovirol 10: 163-170


    Czub S, Czub M, Koutsilieri E, Sopper S, Villinger F, Muller JG, Stahl-Hennig C, Riederer P, Ter Meulen V, Gosztonyi G (2004). Modulation of simian immunodeficiency virus neuropathology by dopaminergic drugs. Acta Neuropathol 107: 216-226


    Scheller C, Ullrich A, McPherson K, Hefele B, Knoferle J, Lamla S, Olbrich AR, Stocker H, Arasteh K, ter Meulen V, Rethwilm A, Koutsilieri E*, Dittmer U* (2004). CpG oligodeoxynucleotides activate HIV replication in latently infected human T cells. J Biol Chem 279: 21897-21902 *equal contributors


    Michel TM, Thome J, Martin D, Nara K, Zwerina S, Tatschner T, Weijers HG, Koutsilieri E (2004). Cu, Zn- and Mn-superoxide dismutase levels in brains of patients with schizophrenic psychosis. J Neural Transm 111: 1191-201


    Scheller C, Sopper S, Koutsilieri E, Ludwig S, Ter Meulen V, Jassoy C (2003). Caspase inhibitors as a supplement in immune activation therapies to achieve eradication of HIV in its latent reservoirs. Ann N Y Acad Sci 1010: 209-212


    Scheller C, Sopper S, Chen P, Flory E, Koutsilieri E, Racek T, Ludwig S, ter Meulen V, Jassoy C (2002). Caspase inhibition activates HIV in latently infected cells. Role of tumor necrosis factor receptor 1 and CD95. J Biol Chem  277: 15459-15464


    Scheller C, Sopper S, Ehrhardt C, Flory E, Chen P, Koutsilieri E, Ludwig S, ter Meulen V, Jassoy C (2002). Caspase inhibitors induce a switch from apoptotic to proinflammatory signaling in CD95-stimulated T lymphocytes. Eur J Immunol  32: 2471-2480


    Koutsilieri E, Scheller C, Sopper S, ter Meulen V, Riederer P (2002).    Psychiatric complications in human immunodeficiency virus infection. J Neurovirol 8:129-33


    Götz ME, Koutsilieri E, Riederer P, Ceccatelli S, Dare E (2002). Methylmercury induces neurite degeneration in primary culture of mouse dopaminergic mesencephalic cells. J Neural Transm 109: 597-605


    Koutsilieri E, Scheller C, Tribl F, Riederer P (2002). Degeneration of neuronal cells due to oxidative stress-microglial contribution. Parkinsonism Relat Disord 8: 401-406


    Koutsilieri E, Scheller C, Sopper S, Gotz ME, Gerlach M, Meulen V, Riederer P (2001). Selegiline completely restores choline acetyltransferase activity deficits in simian immunodeficiency infection. Eur J Pharmacol  411: R1-R2


    Czub* S, Koutsilieri E*, Sopper* S, Czub M, Stahl-Hennig C, Muller JG, Pedersen V, Gsell W, Heeney JL, Gerlach M, Gosztonyi G, Riederer P, ter Meulen V (2001). Enhancement of central nervous system pathology in early simian immunodeficiency virus infection by dopaminergic drugs. Acta Neuropathol 101: 85-91 *(equal contributors)


    Demuth M, Czub S, Sauer U, Koutsilieri E, Haaft P, Heeney J, Stahl-Hennig C, ter Meulen V, Sopper S (2000). Relationship between viral load in blood, cerebrospinal fluid, brain tissue and isolated microglia with neurological disease in macaques infected with different strains of SIV. J Neurovirol 6: 187-201


    Koutsilieri E, Czub S, Scheller C, Sopper S, Tatschner T, Stahl-Hennig C, ter Meulen V, Riederer P (2000). Brain choline acetyltransferase reduction in SIV infection. An index of early dementia? Neuroreport 11: 2391-2393


    Scheller C, Sopper S, Jassoy C, ter Meulen V, Riederer P, Koutsilieri E (2000). Dopamine activates HIV in chronically infected T lymphoblasts. J Neural Transm 107: 1483-1489


    Czub M, Czub S, Gosztonyi G, Koutsilieri E, Sopper S, Muller JG, Gerlach M, Riederer P, ter Meulen V (1999). Effects of Selegiline in a retroviral rat model for neurodegenerative disease. J Neurovirol  5: 458-464


    Koutsilieri E, Sopper S, Heinemann T, Scheller C, Lan J, Stahl-Hennig C, ter Meulen V, Riederer P, Gerlach M (1999). Involvement of microglia in cerebrospinal fluid glutamate increase in SIV-infected rhesus monkeys (Macaca mulatta). AIDS Res Hum Retroviruses 15: 471-477


    Kroemer RT, Koutsilieri E, Hecht P, Liedl KR, Riederer P, Kornhuber J (1998). Quantitative analysis of the structural requirements for blockade of the N-methyl-D-aspartate receptor at the phencyclidine binding site. J Med Chem 41: 393-400


    Gerlach M, Koutsilieri E, Riederer P (1998). N-methyl-(R)-salsolinol and its relevance to Parkinson's disease. Lancet 351: 850-851


    Koutsilieri E, Götz ME, Sopper S, Stahl-Hennig C, Czub M, ter Meulen V, Riederer P (1997). Monoamine metabolite levels in CSF of SIV-infected rhesus monkeys (Macaca mulatta). Neuroreport 8: 3833-3836


    Koutsilieri E, Götz ME, Sopper S, Sauer U, Demuth M, ter Meulen V, Riederer P (1997). Regulation of glutathione and cell toxicity following exposure to neurotropic substances and human immunodeficiency virus-1 in vitro. J Neurovirol  3: 342-349


    Koutsilieri E, Chen TS, Rausch WD, Riederer P (1996). Selegiline is neuroprotective in primary brain cultures treated with 1-methyl-4-phenylpyridinium. Eur J Pharmacol  306: 181-186


    Koutsilieri E, Kornhuber J, Degen HJ, Lesch KP, Sopper S, ter Meulen V, Riederer P (1996). U-373 MG glioblastoma and IMR-32 neuroblastoma cell lines express the dopamine and vesicular monoamine transporters. J Neurosci Res 45: 269-275


    Sopper S, Demuth M, Stahl-Hennig C, Hunsmann G, Plesker R, Coulibaly C, Czub S, Ceska M, Koutsilieri E, Riederer P, Brinkmann R, Katz M, ter Meulen V (1996). The effect of simian immunodeficiency virus infection in vitro and in vivo on the cytokine production of isolated microglia and peripheral macrophages from rhesus monkey. Virology  220: 320-329


    Bringmann G, Feineis D, God R, Fähr S, Weseman W, Clement H-W, Grote C, Kolasiewicz W, Sontag K-H, Heim C, Sontag TA, Reichmann H, Janetzky B, Rausch W-D, Abdel-Mohsen M, Koutsilieri E, Götz ME, Gsell W, Zielke B, Riederer P (1996). Neurotoxic effects on the dopaminergic system induced by TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-b-carboline), a potential mammalian alkaloid: in vivo and in vitro studies. Biogenic Amines 12: 83-102


    Rausch WD, Abdel-mohsen M, Koutsilieri E, Chan WW, Bringmann G (1995). Studies of the potentially endogenous toxin TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline) in neuronal and glial cell cultures. J Neural Transm  46: 255-263


    Koutsilieri E, Chen TS, Kruzik P, Rausch WD (1995). A morphometric analysis of bipolar and multipolar TH-IR neurons treated with the neurotoxin MPP+ in co-cultures from mesencephalon and striatum of embryonic C57BL/6 mice. J Neurosci Res  41: 197-205


    Chen TS, Koutsilieri E, Rausch WD (1995). MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/Bl6 mice. J Neural Transm 100: 153-163


    Koutsilieri E, O'Callaghan JF, Chen TS, Riederer P, Rausch WD (1994). Selegiline enhances survival and neurite outgrowth of MPP(+)-treated dopaminergic neurons. Eur J Pharmacol  269: R3-4


    Chen TS, Koutsilieri E, Kruzik P, Rausch WD (1994). Intracellular calcium and pH as sensitive parameters of toxicity in neural cell culture. ALTEX 11: 216-219


    Koutsilieri E, Chan WW, Reinitzer D, Rausch WD (1993). Functional changes in cocultures of mesencephalon and striatal neurons from embryonic C57/BL6 mice due to low concentrations of 1-methyl-4-phenylpyridinium (MPP+). J Neural Transm  94: 189-197





    Koutsilieri E, Riederer P, du Plessis S, Scheller C (2014). A short review on the relation between the dopamine transporter 10/10-repeat allele and ADHD: implications for HIV infection. Atten Defic Hyperact Disord. PMID:24696011


    Koutsilieri E, Lutz MB, Scheller C (2013). Autoimmunity, dendritic cells and relevance for Parkinson's disease. J Neural Transm 20: 75-81.


    Koutsilieri E, Riederer P. (2007). Excitotoxicity and new antiglutamatergic strategies in Parkinson's disease and Alzheimer's disease. Parkinsonism Relat Disord. 13 Suppl 3: S329-331


    Mössner R, Mikova O, Koutsilieri E, Saoud M, Ehlis AC, Müller N, Fallgatter AJ, Riederer P (2007). Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression. World J Biol Psychiatry 8: 141-174


    Koutsilieri E, Rethwilm A, Scheller C (2007). The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders. J Neural Transm 72: 43-49


    Scheller C, Riederer P, Gerlach M, Koutsilieri E (2006). Induction of proinflammatory signaling due to inhibition of apoptosis in T cells-implications for the CNS. J Neural Transm 71: 45-51


    Scheller C, Ullrich A, Lamla S, Dittmer U, Rethwilm A, Koutsilieri E (2006). Dual activity of phosphorothioate CpG-oligodeoxynucleotides on HIV: Reactivation of latent provirus and inhibition of productive infection in human T cells. Ann N Y Acad Sci  1091: 540-547


    Koutsilieri E, Scheller C, ter Meulen V, Riederer P (2004). Monoamine oxidase inhibition and CNS immunodeficiency infection. Neurotoxicol 25: 267-270 


    Koutsilieri E, Scheller C, Grunblatt E, Nara K, Li J, Riederer P (2002).  Free radicals in Parkinson's disease. J Neurol 249 (Suppl 2): II1-5


    Sopper S, Koutsilieri E, Scheller C, Czub S, Riederer P, ter Meulen V (2002). Macaque animal model for HIV-induced neurological disease. J Neural Transm 109: 747-766


    Koutsilieri E, Scheller C, Sopper S, ter Meulen V, Riederer P (2002). The pathogenesis of HIV-induced dementia. Mech Ageing Dev 123: 1047-1053


    Koutsilieri E, Sopper S, Scheller C, ter Meulen V, Riederer P (2002). Parkinsonism in HIV dementia. J Neural Transm  109: 767-775


    Koutsilieri E, Sopper S, Scheller C, ter Meulen V, Riederer P (2002). Involvement of dopamine in the progression of AIDS Dementia Complex. J Neural Transm 109: 399-410


    Koutsilieri E, ter Meulen V, Riederer P (2002). Neurotransmission in HIV associated dementia: a short review. J Neural Transm 108: 767-775



    Books and Editorials


    Gerlach M, Deckert J, Double K, Koutsilieri E (Eds) (2007). Neuropsychiatric  Disorders:  an Integrative Approach. J Neural Transm Suppl. 72, Springer Wien, New York


    Koutsilieri E, Arendt G, Neuen-Jacob E, Scheller C, Grünblatt E, Riederer P (2006). HIV dementia: a neurodegenerative disorder with viral etiology. In Handbook of Neurochemistry and Molecular Neurobiology, 3rd Edition, Springer, Abel Lajtha (Ed.), volume 25, Degenerative diseases of the nervous system,  chapter 7, 360-367


    Koutsilieri E, Scheller C, Czub S, Sopper S, ter Meulen V, Riederer P (2002). Dopamine is a pathogenetic factor in HIV-induced Neuro-AIDS. In Catecholamine Research: From Molecular Insights to Clinical Medicine. Nagatsu T, Nabeshima T, McCarty R, Goldstein DS (eds), Kluwer Academic/Plenum Publishers, New York, Boston, Dordrecht, London, Moscow. Advances in Behavioural Biology 53: 475-478


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