Intern
    FOR2123

    Sphingolipids in gonococcal infection

    Thomas Rudel

    Dept. of Microbiology, University of Würzburg, Am Hubland, 97074 Würzburg, Germany

    Neisseria gonorrhoeae (green diplococci) invading epithelial cells

    Overview:

    Disseminated gonococcal infection is a serious complication caused by the bacteremic spread of Neisseria gonorrhoeae. Gonococci rapidly invade epithelial and endothelial cells via the scavenger receptor SREC. We could recently demonstrate, that SREC-dependent invasion requires intact detergent-resistant microdomains, caveolin 1 phosphorylation and the involvement of several signaling molecules, including neutral sphingomyelinase 2 (NSMase2), but not of acid SMase (ASMase).

    Published data already suggested ASMase as important enzyme involved in the interaction of gonococci with epithelial and phagocytic cells during acute infection. The major objective of the current project therefore is to understand the role of sphingolipids and NSMases in the course of bacterial invasion during disseminated gonococccal infection.

    Kontakt

    Universität Würzburg
    Sanderring 2
    97070 Würzburg

    Tel.: +49 931 31-0
    Fax: +49 931 31-82600

    Suche Ansprechpartner

    Sanderring Röntgenring Hubland Nord Hubland Süd Campus Medizin