Deutsch Intern
    Institut für Virologie und Immunbiologie

    Silva-Vilches, C., Pletinckx, K., Lohnert, M., Pavlovic, V., Ashour, D., Vini, J., Vendelova, E., Kneitz, S., Zhou, J., Chen, R., Reinheckel, T., Müller, T.D., Bodem, J., and Lutz, M.B. (2017) Low Doses of Cholera Toxin and its Mediator cAMP Induce CTLA-2 Secretion by Dendritic Cells to Enhance Regulatory T Cell Conversion. PLOS One in press.

    Spannaus, R., Miller, C., Lindemann, D. and Bodem, J. 2017. Purification of foamy viral particles. Virology 506:28-33. DOI: 10.1016/j.virol.2017.03.005.

    Moschall, R., Denk, S., Erkelenz, S., Schenk, C., Schaal, H., and Bodem, J. 2017. A purine-rich element in foamy virus pol regulates env splicing and gag/pol expression. Retrovirology,14:10 DOI: 10.1186/s12977-017-0337-6.

    Schneider, A., Corona, A., Spöring, I., Jordan, M., Buchholz, B., Maccione, E., Di Santo, R., Bodem, J., Tramontano, E., and Wöhrl, B. 2016. Biochemical characterization of a multi-drug resistant HIV-1 subtype AG Reverse Transcriptase: Antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors. NAR, Nucleic Acids Research, 2016 1 doi: 10.1093/nar/gkw060.

    De Sousa, L.R.F., Wu, H., Nebo, L., Fernandes, J.B., Da Silva, M.F.G.F., Kiefer, W., Kanitz, M., Bodem, J., Diederich, W.E., Schirmeister, T., and Cezar, V. 2015. Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies. Bioorganic and Medicinal Chemistry, 2015 Feb 1; 23(3):466-70.

    Wu, H., Bock, S., Snitko, S., Berger, T., Weidner, T., Holloway, S., Kanitz, M., Diederich, W.E., Steuber, H., Walter, C., Hofmann, D., Weißbrich, B., Spannaus, R.,  Acosta, E.G., Bartenschlager, R., Engels, B., Schirmeister, T., and Bodem, J. 2014. Novel Dengue virus NS2B/NS3 protease inhibitors. Antimicrob Agents Chemother, 2015 Feb; 59(2):1100-9.

    Spannaus, R., and Bodem, J. 2014. Determination of the protease cleavage site repertoire - the RNase H but not the RT domain is essential for foamy viral protease activity. Virology, 454-455:145-156.

    Schrom, EM., Moschall, R., Hartl, MJ., Weitner, H., Fecher, D., Langemeier, J., Bohne, J., Wöhrl, MB. and Bodem, J. 2013. U1snRNP-mediated suppression of polyadenylation in conjunction with the RNA structure controls poly(A) site selection in foamy viruses. Retrovirology, 10:55.

    Spannaus, R.,  Schneider, A.,  Hartl, M.,  Wöhrl, MB and Bodem, J. 2013. Foamy viral Gag p71/p68 cleavage is required for template switch of the reverse transcriptase J. Virol., 87:7774-7776.

    Schrom, EM., Moschall, R., Schuch, A., and Bodem, J. 2013. Regulation of retroviral polyadenylation.  Adv. Virus Res 85, 1-24.

    Langemeier, J., Schrom, EM., Rabner, A., Radtke, M., Zychlinski, D., Saborowski, A., Bohn, G., Mandel-Gutfreund, Y., Bodem, J., Klein, C., and Bohne, J. 2012. U1 snRNP-mediated poly(A) site suppression is the molecular basis of a complex immunodeficiency. EMBO J, doi: 10.1038/emboj.2012.252.

    Jacobs, GB, Bock, S., Schuch, A., Moschall, R., Schrom, EM, Zahn, J., Reuter, Ch., Preiser, W., Rethwilm, A., Engelbrecht, S., Kerkau, T., Bodem, J. 2012. Construction of a high titer infectious HIV-1 subtype C proviral clone from South Africa. Viruses 4,1830-1843.

    Kožíšek, M., Henke, S., Grantz Šašková, K., Jacobs, GB, Schuch, A., Buchholz, B., Müller, V., Kräusslich, HG, Řezáčová, P., Konvalinka, J. and Bodem, J. 2012. Mutations in HIV-1 gag and pol compensate for the loss of viral fitness caused by a highly mutated protease. Antimicrob Agents Chemother. doi:10.1128/AAC.00465-12.  

    Spannaus, R., Hartl, MJ., Wöhrl, BM., Rethwilm, A. and Bodem, J. 2012. The prototype foamy virus protease is active independently of the integrase domain. Retrovirology 9, 41.

    Kasang, C., Kalluvya, S., Majinge, C., Stich, A., Bodem, J., Kongola, G., Jacobs, GB, Mllewa, M., Mildner, M., Hensel, I., Horn, A., Preiser, W., van Zyl, G., Klinker, H., Koutsilieri, E., Rethwilm, A., Scheller, C. and Weissbrich, B. 2011. The prevalence of drug resistant HIV in therapy-naive patients in Tanzania is significantly higher than estimated by WHO surveillance criteria. PLoS ONE 6, e23091. doi:10.1371/journal.pone.002309129.

    Hartl, MJ, Bodem, J., Jochheim, F., Rethwilm, A., Rösch, P. and Wöhrl, BM. 2011. Regulation of foamy virus protease activity by viral RNA - a novel and unique mechanism among retroviruses. J. Virol. 85, 4462-4469.

    Matthes, D., Wiktrorowicz, T., Zahn, J., Bodem, J., Stanke, N., Lindemann, D. and Rethwilm, A. 2011. Basic residues in the foamy virus Gag protein. J. Virol. 85, 3986-3995.

    Schulze, A., Lemey, P., Schubert, J., McClure, MO, Rethwilm, A. and Bodem, J. 2011. Complete nucleotide sequence and evolutionary analysis of a Gorilla foamy virus. J. Gen. Virol. 92, 582-586.

    Bodem, J., Schied, T., Gabriel, R., Rammling, M. and Rethwilm, A. 2011. Foamy virus nuclear RNA export is distinct from that of other retroviruses. J. Virol. 85, 2333-2341.

    Hartl, MJ, Schweimer, K., Reger, MH, Schwarzinger, S., Bodem, J., Rösch, P. and Wöhrl, BM. 2010. Formation of transient dimers by a retroviral protease. Biochem. J. 427,197-203.

    Kowalzik, S., Xuan, NV, Weissbrich, B., Scheiner, B., Schied, T., Drosten, C., Müller, A., Stich, A., Rethwilm, A. and Bodem, J. 2008. Characterisation of a chikungunya virus from a German patient returning from Mauritius and development of a serological test. Med. Mecrobiol. Immunol. 197, 381-386.

    Thümer, L., Rethwilm, A., Holmes, E. and Bodem J. 2007. The complete nucleotide sequence of a New World simian foamy virus. Virology. 369, 191-197.

    Bodem, J., Kräusslich, HG and Rethwilm, A. 2007. Acetylation of the foamy virus transactivator Tas by PCAF augments promoter-binding affinity and virus transcription. J. Gen. Virol. 88, 259-263.

    Sticht, J., Humbert, M., Findlow, S., Bodem, J., Müller, B., Dietrich, U., Werner, J. and Kräusslich, HG. 2005. A peptide inhibitor of HIV-1 assembly in vitro. Nat. Struct. Mol. Biol. 12, 671-677.

    Cígler, P., Kozíek, M., Rezácová, P., Brynda, J., Otwinowski, Z., Pokorná, J., Plesek, J., Grüner, B., Dolecková-Maresová, L., Mása, M., Sedládek, J., Bodem, J., Kräusslich, HG, Král, V. and Konvalinka, J. 2005. From nonpeptide toward noncarbon protease inhibitors: metallacarbonares as specific and potent inhibitors of HIV protease. Proc. Natl. Acad. Sci. USA. 102, 15394-15399.

    Bodem, J. 2011. Regulation of foamy viral transcription and RNA export. Advances in Virology. 81:1-31




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