Deutsch Intern
    Institut für Virologie und Immunbiologie



    Selected publications:

     
    1) Beyersdorf N, Hanke T, Kerkau T, Hünig T. 2006

    CD28 superagonists put a break on autoimmunity by preferentially activating CD4+CD25+ regulatory T cells.
    Autoimmun Rev. 5: 40-45.

    2) Beyersdorf N, Hanke T, Kerkau T, Hünig T . 2005
    Superagonistic anti-CD28 antibodies: potent activators of regulatory T cells for the therapy of autoimmune diseases.
    Ann Rheum Dis 64: 91-95.

    3) Beyersdorf N, Gaupp S, Balbach K, Schmidt J, Toyka KV, Lin CH, Hanke T, Hünig T, Kerkau T, Gold R. 2005
    Selective targegting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis..
    J Exp Med 202: 445-455.

    4) Elflein K, Rodriguez-Palmero M, Kerkau T, Hünig T. 2003
    Rapid recovery from T lymphopenia by CD28 superagonist therapy.
    Blood: in print.

    5) Lühder F, Huang Y, Dennehy KM, Guntermann C, Müller I, Winkler E, Kerkau T, Ikemizu S, Davis SJ, Hanke T, Hünig T. 2003
    Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists.
    J Exp Med 197: 955-66.

    6) Kutsch O, Vey T, Kerkau T, Hünig T, Schimpl A. 2002
    HIV type I abrogates TAP-mediated transport of antigenic peptides presented by MHC class I. Transporter associated with
    antigen expression.
    AIDS Res Hum Retroviruses 18: 1319-25.

    7) Halbach A, Nierwetberg D, Muller JG, Sauer U, Kerkau T, Stolte N, Hofmann P,
    Czub S, ter Meulen V, Sopper S. 2000.
    Total numbers of lymphocyte subsets in different lymph node regions of uninfected and SIV-infected macaques.
    J Med Primatol 29: 148-57.

    8) Neben K, Heidbreder M, Muller J, Marxer A, Petry H, Didier A, Schimpl A,
    Hunig T, Kerkau T. 1999.
    Impaired thymopoietic potential of immature CD3(-)CD4(+)CD8(-) T cell precursors from SIV-infected rhesus monkeys.
    Int Immunol 11: 1509-18.

    9) Kerkau T., I.Bacik, J.R. Bennink, J.W. Yewdell, T. Hünig, A. Schimpl and U. Schubert. 1997.
    The human immunodeficiency virus type 1 (HIV-1) Vpu protein interferes with an early step in the biosynthesis of major histocompatibility
    complex (MHC) class I molecules.
    The Journal of Experimental Medicine 185: 1295-1305.

    10) Müller J., V. Krenn, C. Schindler, S. Czub, C. Stahl-Hennig, C. Coulibaly, G. Hunsmann, C. Kneitz, T. Kerkau, A. Rethwilm, V. ter Meulen and H.K. Müller-Hermelink. 1993.
    Alterations of thymus cortical epithelium and interdigitating dendritic cells but no increase of thymocyte cell death in the early course of simian
    immunodeficiency virus infection.
    American Journal of Pathology 143: 699-713.


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