Research Topics Lutz Lab
The objectives of our research are to understand the peripheral tolerance mechanisms of the immune system under healthy conditions and when exploited by microbial immune evasion. From these type of analyses we learn how immunological tolerance can be re-established in diseases such as autoimmunity and allergy or can be applied to prevent transplant rejections.
We investigate the molecular basis behind the tolerogenicity of:
1. Immature and semi-mature dendritic cells (DCs)
2. Anergic and regulatory T cells (Foxp3+ iTregs versus Foxp3- IL-10+ Tr1)
3. Myeloid-derived suppressor cells (MDSC).
The effects of these cells and their molecular mechanisms are studied by using gene-modified mice (transgenic, knock-out, Cre-lox systems) mouse models of mycobacterial infection (Mtb/BCG) as well as autoimmunity (EAE) and allergy (OVA-asthma). Clinical approaches to establish tolerogenic vaccines are tested in a type I allergy of horses.
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